Neuronal expression of constitutive heat shock proteins: implications for neurodegenerative diseases
Identifieur interne : 002451 ( Main/Exploration ); précédent : 002450; suivant : 002452Neuronal expression of constitutive heat shock proteins: implications for neurodegenerative diseases
Auteurs : Sheng Chen ; Ian R. BrownSource :
- Cell Stress & Chaperones [ 1355-8145 ] ; 2007.
Abstract
Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis have been termed “protein misfolding disorders.” These diseases differ widely in frequency and impact different classes of neurons. Heat shock proteins provide a line of defense against misfolded, aggregation-prone proteins and are among the most potent suppressors of neurodegeneration in animal models. Analysis of constitutively expressed heat shock proteins revealed variable levels of Hsc70 and Hsp27 in different classes of neurons in the adult rat brain. The differing levels of these constitutively expressed heat shock proteins in neuronal cell populations correlated with the relative frequencies of the previously mentioned neurodegenerative diseases.
Url:
DOI: 10.1379/CSC-236R.1
PubMed: 17441507
PubMed Central: 1852893
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000298
- to stream Pmc, to step Curation: 000298
- to stream Pmc, to step Checkpoint: 000C02
- to stream Ncbi, to step Merge: 000754
- to stream Ncbi, to step Curation: 000754
- to stream Ncbi, to step Checkpoint: 000754
- to stream Main, to step Merge: 002679
- to stream Main, to step Curation: 002451
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuronal expression of constitutive heat shock proteins: implications for neurodegenerative diseases</title>
<author><name sortKey="Chen, Sheng" sort="Chen, Sheng" uniqKey="Chen S" first="Sheng" last="Chen">Sheng Chen</name>
</author>
<author><name sortKey="Brown, Ian R" sort="Brown, Ian R" uniqKey="Brown I" first="Ian R." last="Brown">Ian R. Brown</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">17441507</idno>
<idno type="pmc">1852893</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852893</idno>
<idno type="RBID">PMC:1852893</idno>
<idno type="doi">10.1379/CSC-236R.1</idno>
<date when="2007">2007</date>
<idno type="wicri:Area/Pmc/Corpus">000298</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000298</idno>
<idno type="wicri:Area/Pmc/Curation">000298</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000298</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000C02</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C02</idno>
<idno type="wicri:Area/Ncbi/Merge">000754</idno>
<idno type="wicri:Area/Ncbi/Curation">000754</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000754</idno>
<idno type="wicri:doubleKey">1355-8145:2007:Chen S:neuronal:expression:of</idno>
<idno type="wicri:Area/Main/Merge">002679</idno>
<idno type="wicri:Area/Main/Curation">002451</idno>
<idno type="wicri:Area/Main/Exploration">002451</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Neuronal expression of constitutive heat shock proteins: implications for neurodegenerative diseases</title>
<author><name sortKey="Chen, Sheng" sort="Chen, Sheng" uniqKey="Chen S" first="Sheng" last="Chen">Sheng Chen</name>
</author>
<author><name sortKey="Brown, Ian R" sort="Brown, Ian R" uniqKey="Brown I" first="Ian R." last="Brown">Ian R. Brown</name>
</author>
</analytic>
<series><title level="j">Cell Stress & Chaperones</title>
<idno type="ISSN">1355-8145</idno>
<idno type="eISSN">1466-1268</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis have been termed “protein misfolding disorders.” These diseases differ widely in frequency and impact different classes of neurons. Heat shock proteins provide a line of defense against misfolded, aggregation-prone proteins and are among the most potent suppressors of neurodegeneration in animal models. Analysis of constitutively expressed heat shock proteins revealed variable levels of Hsc70 and Hsp27 in different classes of neurons in the adult rat brain. The differing levels of these constitutively expressed heat shock proteins in neuronal cell populations correlated with the relative frequencies of the previously mentioned neurodegenerative diseases.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Brown, Ian R" sort="Brown, Ian R" uniqKey="Brown I" first="Ian R." last="Brown">Ian R. Brown</name>
<name sortKey="Chen, Sheng" sort="Chen, Sheng" uniqKey="Chen S" first="Sheng" last="Chen">Sheng Chen</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002451 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002451 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:1852893 |texte= Neuronal expression of constitutive heat shock proteins: implications for neurodegenerative diseases }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:17441507" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonCanadaV1
This area was generated with Dilib version V0.6.29. |